GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2275426 | 1 | rs11211234 | chr1:46438787 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs11211241 | chr1:46452683 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs494003 | 1 | rs11227284 | chr11:65503224 | SNX32 | chr11:65601410-65621170:+ | 0.43 | 4.57 | 1.48E-5 | Systemic lupus erythematosus |
| THYM | cis | rs494003 | 1 | rs11227288 | chr11:65516588 | SNX32 | chr11:65601410-65621170:+ | 0.41 | 4.48 | 2.05E-5 | Systemic lupus erythematosus |
| THYM | cis | rs11799420 | 1 | rs112293138 | chr1:171714002 | VAMP4 | chr1:171669298-171711214:- | 0.34 | 4.39 | 2.94E-5 | Hippocampal atrophy |
| THYM | cis | rs2463822 | 1 | rs11231050 | chr11:62131660 | ASRGL1 | chr11:62104774-62160885:+ | -0.51 | -5.37 | 5.53E-7 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs7969151 | 1 | rs112326077 | chr12:54158264 | COPZ1 | chr12:54718911-54745633:+ | -0.3 | -4.54 | 1.64E-5 | Tanning |
| THYM | cis | rs7072122 | 1 | rs11239102 | chr10:45009625 | ZNF22 | chr10:45496273-45500776:+ | 0.45 | 4.58 | 1.43E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs11239105 | chr10:45013614 | ZNF22 | chr10:45496273-45500776:+ | 0.57 | 5.19 | 1.21E-6 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs11239106 | chr10:45013624 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.61 | 1.27E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs11239111 | chr10:45016980 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.63 | 1.16E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs11239120 | chr10:45034301 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.61 | 1.27E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs11239124 | chr10:45042411 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.63 | 1.16E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs7072122 | 1 | rs11239132 | chr10:45055615 | ZNF22 | chr10:45496273-45500776:+ | 0.57 | 5.19 | 1.21E-6 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs2564921 | 1 | rs11242 | chr3:53125922 | RFT1 | chr3:53122503-53164470:- | 0.44 | 4.91 | 3.78E-6 | Height |